This study investigated sociological variables and gender on students’ drop-out among senior secondary school students in Potiskum Local Government Area of Yobe State. Three research questions and one hypothesis guided the study. A sample of 222 respondents was selected from the total population of 233 public senior secondary school teachers in Potiskum LGA. The sample size was determined through multi-stage sampling technique of purposive, proportionate and simple random sampling technique. A self-designed questionnaire was employed as instrument for data collection and was validated and a reliability index of .84. The instrument was administered by the researchers with the help of research assistant in each school where the research was conducted. The data collected were analysed with the use of simple statistical tools of frequency counts and percentages was well as independent sample t-test. The result obtained showed that the respondents attested to the fact that the items on the instrument indicate influence of peer group on students’ drop out in school; indicates that the respondents detested to the fact that the items on the instrument indicate teachers’ attitude on students’ drop out in school; and the finding shows that male and female teachers do not significantly differ in their expression on the rate of school dropout. The study concluded that peer group influences students’ drop out in school; teachers’ attitude do not lead to students’ drop out in school; and male and female teachers do not significantly differ in their expression on the rate of school dropout. Thus, recommendation was made among others that, both male and female teachers should make sure that they show positive attitude to their students to ensure that they do not become drop out of school.