In order to educate the nation's life, improving the quality of education is important for sustainable development in all aspects of human life. This study uses a quantitative approach with an experimental method. The population in this study were students of SMK Muhammadiyah Manado. The research sample was the students of class X Nursing as the control class and those using the scientific learning model of class X TKJ students as the experimental class. The type of sample used in this study is a simple random sampling technique. This study uses a 2 X 2 factorial design, so a two-way analysis of variance (Two Way ANOVA) is used, which is the method used to test differences in variance of two or more variables. The main elements in the analysis of variance are the variance between groups and the variance within groups. The learning outcomes of simulation and digital communication in the group of students who were taught using a science-based learning model were higher than the group of students who were taught using a lecture-based learning model.