Comprehensive Partnership and Transpacific Progress (CPTPP) is a free trade agreement between countries on the Pacific coast, aiming to eliminate 90% or more of the tariff barriers for goods and services of partners participating in the agreement. Vietnam expects to benefit from CPTPP, but there are many difficulties waiting ahead. When the agreement is signed, a large number of highly skilled workers from the countries will join the labor market in Vietnam, creating competition with domestic workers, in addition to creating motivation for development of high-level human resource as well as the approach to education of Vietnamese universities. The article addresses the opportunities and challenges of the Vietnamese labor market when implementing labor commitments in CPTTP, there by giving some recommendations on policies for the government and related authorities.