The present study was conducted to find out the effect of teaching aptitude along with neuroticism dimension of personality on teacher effectiveness. This study was conducted on 320 female teachers. Stratified random sampling was used to select female teachers working in government schools located in and around Raipur Chhattisgarh. Hindi version of Eysenck Personality Questionnaire (EPQ) prepared by Jitendra Mohan (1985) was used to assess neuroticism while Hindi version of Teaching Aptitude Test Battery prepared by Singh and Sharma (1986) was used to assess teaching aptitude of selected female teachers. Teacher effectiveness used as a dependent variable in the present study was assessed by scale prepared by Kumar and Mutha (1983). Results showed significant main effect of neuroticism and teaching aptitude on teacher effectiveness but interaction effect of these two variables was not observed on teacher effectiveness. It was concluded that neuroticism and teaching aptitude alone and not in interaction with each other influence teacher effectiveness in a group of female teachers.