The intention of this study is to find out the relationship between teacher effectiveness and attitude of secondary school teachers towards their teaching profession. The sample comprised 100 teachers serving in secondary schools of Bangalore South District selecting by simple random sampling technique The Attitude Scale towards Teaching Profession (2008) and Teacher Effectiveness Scale (2006) both were developed and standardized by Kulsum was utilized for data collection. The Pearson’s Product Moment Coefficient of Correlation, ‘t’, ‘F’ Tests and Scheffe’s Post Hoc test were applied to test the formulated hypotheses. The correlation result shows significant positive relationship between Teacher Effectiveness and attitude of teachers towards teaching profession and ‘t’ test found significant difference exists between male and female teachers on their teacher effectiveness and their attitude towards profession and also from the ‘F’ test shows that different levels of attitude were influenced on Teacher Effectiveness. The female teachers had more better effectiveness in teaching and also better favourable attitudes towards profession. The teachers having favourable attitudes had more effectiveness in teaching when compared with moderate and unfavourable attitude towards teaching profession.