Objectives: The aim of the present study was to explore the relationship of perceived social support (support from family, support from friends and support from significant others) and meaning in life (presence of meaning in life and search for meaning in life) with fighting spirit (Mental adjustment) among cancer patients. The integrative effect of perceived social support and meaning in life on fighting spirit was also investigated. Method: The sample of the study consisted of 200 cancer patients who were selected on purposive basis from Shri Maharaja Hari Singh Hospital, Srinagar, J&K and Jawahar Lal Nehru Medical College, Aligarh, Uttar Pradesh. The tools used for the present study were Meaning in Life Questionnaire (MLQ) developed by Steger, et al., (2006); Multidimensional Scale of Perceived Social Support scale (MSPSS) developed by Zimet (1988), and The Mental Adjustment to Cancer Scale developed by (Watson et al., 1988). The data collected was analyzed by using appropriate statistical techniques like Pearson’s product moment correlation and stepwise multiple regression analysis. Results: The results showed significant positive correlation between support from family and fighting spirit (r=.210, p>.001); support from friends and fighting spirit (.295 p>.001); support from significant others and fighting spirit (r=.335, p>.001); overall perceived social support and fighting spirit (r=.379, p>.001); meaning in life and fighting spirit (r=.218, p>.001) and between presence of meaning in life (X5) and fighting spirit. However, there was a significant negative correlation between search for meaning in life and fighting spirit (r=-.364 p>.001) among cancer patients. Hierarchical regression analyses indicated that social support and meaning in life as a whole accounted for 35.56% variance of fighting spirit. Conclusion: The findings of the study revealed that perceived social support and meaning in life have a significant positive correlation with fighting spirit. The largest Beta value of presence of meaning in life (b=.439, t= 6.909, p<.0001) suggests that it made the strongest unique contribution in explaining fighting spirit and; the Beta value of support from friends was lower (b=.172, t= 2.712, p<.007) which suggests that it made less of a contribution.