Patients with chronic illness develop psychological distress, anxiety issues, stress and eventually their quality of life and satisfaction with life deteriorates. Such patients need to be resilient enough to fight with such adversity and stressors and be optimistic in their approach towards life. The current investigation was designed to study the interrelationship between resilience and optimism among chronically ill patients. The sample for the current investigation consisted of 40 chronically ill female patients in the age group of 30-40 years from the hospitals of the tricity of Panchkula, Mohali and Chandigarh. For this purpose, Life Orientation Test Revised (LOT-R) (Scheier, Carver & Bridges, 1994) and Resilience Scale (Wagnild, 2009) were administered to the sample. Inter- correlational analysis was used for statistical analysis. Results were discussed in terms of its implications.