Abstract Numerous research studies have established clear links between a positive state of mind and good physical health. There are many other studies that suggest deliberately cultivating a positive state of mind can help fight off ill health. Objective: - The purpose of this investigation was to Comparison of Health Related Life Style among Different Indian Professions in Relation to spiritual wellness Assessment. Method: - 800 males of MP were selected randomly as a subject of study. The age of the subjects were ranged from 30-40 years. Subjects were from different professions each group has 1 subjects. All the contents related to life style were assessed by using life style assessment inventory (LSAI). Results: - ANOVA was used to reveal the significance difference among Different Indian Professions in Relation to spiritual wellness Assessment. Level of significant was set at 0.05. A significant difference was found among Different Indian Professions in Relation to spiritual wellness Assessment. Conclusion: - It can be concluded that spiritual wellness Assessment significantly differs among Different Indian Professions.