Background: An arteriovenous (AV) fistula is a type of access used for hemodialysis. It can be used whether dialysis is performed at a dialysis center. An AV fistula is a connection between an artery and a vein creating a ready source with a rapid flow of blood. The fistula is located under the skin and is used during dialysis to access the bloodstream.

Objective: To assess the knowledge regarding A.V. fistula care & exercise.

Materials and methods: Descriptive research design and simple random sampling technique was followed which included 30 samples were used. Data was collected through structured knowledge questionnaire on A.V. fistula care & exercise. Data analysis was done with descriptive and inferential statistics.

Results: Among hemodialysis patients, 15 (50%) had adequate knowledge level and 15(50%) had inadequate knowledge on A.V. fistula care and Exercise.

Conclusion: The study concluded that 15(50%) had adequate knowledge on A.V. fistula care & exercise